Fosinopril intermediate
[2-Methyl-l-(l-Oxopropoxy)Propoxy][(4-Phenylbutyl)Phosphinyl]Acetic Acid
CAS: 123599-78-0
Molecular Formula: C19H29O6P
Fosinopril intermediate - Names and Identifiers
| Name | [2-Methyl-l-(l-Oxopropoxy)Propoxy][(4-Phenylbutyl)Phosphinyl]Acetic Acid |
| Synonyms | Fosinopril intermediate rac-Des(4-cyclohexyl-L-proline) Fosinopril Acetic Acid [(2-Methyl-1-propionylpropoxy)(4-phenylbutyl)phosphinoyl]acetic acid [(2-Methyl-1-Propionylpropoxy)(4-Phenylbutyl)Phosphinoyl]Acetic Acid 2-(((2-Methyl-4-oxohexan-3-yl)oxy)(4-phenylbutyl)phosphoryl)acetic acid [[2-Methyl-l-(l-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid [2-Methyl-l-(l-Oxopropoxy)Propoxy][(4-Phenylbutyl)Phosphinyl]Acetic Acid 2-[(2-methyl-1-propanoyloxy-propoxy)-(4-phenylbutyl)phosphoryl]acetic acid rac-2-[[2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic Acid |
| CAS | 123599-78-0 |
| EINECS | 602-944-4 |
| InChI | InChI=1/C19H29O6P/c1-4-18(22)24-19(15(2)3)25-26(23,14-17(20)21)13-9-8-12-16-10-6-5-7-11-16/h5-7,10-11,15,19H,4,8-9,12-14H2,1-3H3,(H,20,21) |
Fosinopril intermediate - Physico-chemical Properties
| Molecular Formula | C19H29O6P |
| Molar Mass | 384.4 |
| Density | 1.153g/cm3 |
| Melting Point | 48 - 55°C |
| Boling Point | 519.8°C at 760 mmHg |
| Flash Point | 268.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.24E-11mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White Low Melting |
| Storage Condition | 2-8°C |
| Refractive Index | 1.503 |
Fosinopril intermediate - Introduction
[2-Methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid is an organic compound with the following properties:
1. appearance: the common form is colorless to light yellow liquid.
2. Solubility: It dissolves in many organic solvents, such as ethanol, ether and dichloromethane.
3. Stability: The compound is relatively stable to air and water, but may undergo decomposition reaction at high temperature.
4. odor: the compound has a pungent odor.
[2-methyl -1-(1-oxopropoxy) propoxy](4-phenyl butyl) phosphinyl] acetic acid is mainly used as follows:
1. Coordination reagent: It can be used as a ligand of metal complexes to form stable complexes with metals.
2. Catalyst: It can be used as a catalyst for organic synthesis reactions, such as the synthesis of oxalic esters.
3. Weather resistance additive: It can be used as an additive for polymers to improve their weather resistance and chemical corrosion resistance.
The method of preparing [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid includes the following steps:
1. Starting material: A compound of 2-methyl -1-(1-oxopropoxy) propanol and 4-phenylbutylpiperidine was obtained.
2. Preparation of phosphine compound: 2-methyl -1-(1-oxopropoxy) propanol is reacted with 4-phenylbutylpiperidine to generate [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine.
3. Rereaction: [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine is reacted with phosphine trichloride to give the final product [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid.
For safety information, the following precautions need to be observed:
1. Storage: The compound should be kept away from fire and oxidizing agents, and stored in a sealed container, away from direct sunlight.
2. use: when in use should pay attention to avoid inhalation, chewing or swallowing, contact with skin or eyes should immediately rinse with plenty of water.
3. Waste disposal: Local regulations should be followed to properly dispose of waste and not discharge it into water bodies or the environment.
1. appearance: the common form is colorless to light yellow liquid.
2. Solubility: It dissolves in many organic solvents, such as ethanol, ether and dichloromethane.
3. Stability: The compound is relatively stable to air and water, but may undergo decomposition reaction at high temperature.
4. odor: the compound has a pungent odor.
[2-methyl -1-(1-oxopropoxy) propoxy](4-phenyl butyl) phosphinyl] acetic acid is mainly used as follows:
1. Coordination reagent: It can be used as a ligand of metal complexes to form stable complexes with metals.
2. Catalyst: It can be used as a catalyst for organic synthesis reactions, such as the synthesis of oxalic esters.
3. Weather resistance additive: It can be used as an additive for polymers to improve their weather resistance and chemical corrosion resistance.
The method of preparing [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid includes the following steps:
1. Starting material: A compound of 2-methyl -1-(1-oxopropoxy) propanol and 4-phenylbutylpiperidine was obtained.
2. Preparation of phosphine compound: 2-methyl -1-(1-oxopropoxy) propanol is reacted with 4-phenylbutylpiperidine to generate [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine.
3. Rereaction: [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) piperidine is reacted with phosphine trichloride to give the final product [2-methyl -1-(1-oxopropoxy) propoxy] (4-phenylbutyl) phosphinyl] acetic acid.
For safety information, the following precautions need to be observed:
1. Storage: The compound should be kept away from fire and oxidizing agents, and stored in a sealed container, away from direct sunlight.
2. use: when in use should pay attention to avoid inhalation, chewing or swallowing, contact with skin or eyes should immediately rinse with plenty of water.
3. Waste disposal: Local regulations should be followed to properly dispose of waste and not discharge it into water bodies or the environment.
Last Update：2024-04-09 20:02:46
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